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7651 - UniS MSc in Diabetes A population approach Impaired...

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MSc in Diabetes A population approach Ross Lawrenson Postgraduate Medical School University of Surrey Impaired glucose tolerance and undiagnosed diabetes Uni S   
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Metabolic syndrome Impaired glucose tolerance Undiagnosed Type 2 diabetes
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Theories on the aetiology of Type 2 diabetes Barker hypothesis Reaven Syndrome Thrifty genotype
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Barker hypothesis The thrifty phenotype
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Odds ratio of NIDDM and IGT related to birth weight 0 1 2 3 4 5 6 7 8 <=5.5 5.5-6.4 6.5-7.4 7.5-8.4 8.5-9.4 >9.5 Birth Weight in pounds Odds Ratio
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Barker hypothesis Malnutrition in the prenatal and early infant years. ( Hales and Barker ) Beta cells increase of 130 times between 12 th intra-uterine week and 5 th post natal month. Malnutrition. Obesity in later life.
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Reaven syndrome First described by Himsworth in 1936 Described in New Zealand by Ian Prior in 1966 in Maori (obesity, hypertension diabetes and gout) Syndrome X sometimes called Reaven syndrome after Gerry Reaven
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Relationship between glucose uptake and fasting plasma glucose 0 100 200 300 400 500 600 700 0 50 100 150 200 250 300 Normal IGT NIDDM Reaven G. Diabetes 1988
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