20261 - New Feature of NCEP ATP III Identification of the...

Info icon This preview shows pages 1–12. Sign up to view the full content.

View Full Document Right Arrow Icon
March 8, 2012 1 Risk Factor Defining Level Abdominal obesity (waist circumference ) Men >102 cm (>40 in) Women >88 cm (>35 in) Triglycerides 150 mg/dL HDL cholesterol Men <40 mg/dL Women <50 mg/dL Blood pressure 130/ 85 mm Hg Fasting glucose 110 mg/dL Positive diagnosis based on the presence of three or more of the following: New Feature of NCEP ATP III:* Identification of the Metabolic Syndrome
Image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
March 8, 2012 2 INSULIN RESISTANCE An impaired biological response to insulin Resistance to insulin-stimulated glucose uptake An impairment of normal glucose uptake by muscle Unregulated overproduction of glucose by the liver Core defect in T2DM Underlying defect in the metabolic syndrome (clinical picture)
Image of page 2
March 8, 2012 3 Visceral obesity is associated with a cluster of metabolic abnormalities
Image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
March 8, 2012 4 Metabolic Syndrome: Total and CV Mortality in Middle-Aged Men in Kuopio Heart Study Cardiovascular Disease Mortality 0 2 8 10 12 4 6 0 5 10 15 20 All-Cause Mortality 0 2 8 10 12 4 6 0 5 10 15 20 Cumulative Hazard (%) No. at Risk Metabolic Syndrome Yes 866 852 834 292 No 288 279 234 100 Yes 866 852 834 292 No 288 279 234 100 Follow-up (Years) Follow-up (Years) RR (85% CI) 2.13 (1.64-3.61) RR (85% CI) 3.55 (1.96-6.43) Metabolic Syndrome Yes No Metabolic Syndrome Yes No
Image of page 4
March 8, 2012 5
Image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
March 8, 2012 6
Image of page 6
March 8, 2012 7
Image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
March 8, 2012 8 ROLE OF PEROXISOME PROLIFERATOR- ACTIVATED RECEPTORS PPARs—Steroid hormone nuclear receptors Act as ligand-activated transcription factors Control expression of specific target genes Protein products control a variety of cellular functions PPAR-alpha family is a critical regulator of fatty acid metabolism Expressed throughout vasculature; limits adhesion molecule expression,tissue factor production PPAR-gamma family plays central role in fatty tissue production,fat metabolism,glucose regulation Highly expressed in endothelial cells,smooth muscle cells,lymphocytes,macrophages
Image of page 8
March 8, 2012 9
Image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
March 8, 2012 10 PPARa regulates Apo A-I, Apo A-II, LPL, ABCA-1 and SR-BI expression
Image of page 10
March 8, 2012 11
Image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 12
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern