20261 - New Feature of NCEP ATP III:* Identification of the...

Info iconThis preview shows pages 1–12. Sign up to view the full content.

View Full Document Right Arrow Icon
March 8, 2012 1 Risk Factor Defining Level Abdominal obesity (waist circumference ) Men >102 cm (>40 in) Women >88 cm (>35 in) Triglycerides 150 mg/dL HDL cholesterol Men <40 mg/dL Women <50 mg/dL Blood pressure 130/ 85 mm Hg Fasting glucose 110 mg/dL Positive diagnosis based on the presence of three or more of the following: New Feature of NCEP ATP III:* Identification of the Metabolic Syndrome
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
March 8, 2012 2 INSULIN RESISTANCE An impaired biological response to insulin Resistance to insulin-stimulated glucose uptake An impairment of normal glucose uptake by muscle Unregulated overproduction of glucose by the liver Core defect in T2DM Underlying defect in the metabolic syndrome (clinical picture)
Background image of page 2
March 8, 2012 3 Visceral obesity is associated with a cluster of metabolic abnormalities
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
March 8, 2012 4 Metabolic Syndrome: Total and CV Mortality in Middle-Aged Men in Kuopio Heart Study Cardiovascular Disease Mortality 0 2 8 10 12 4 6 0 5 10 15 20 All-Cause Mortality 0 2 8 10 12 4 6 0 5 10 15 20 Cumulative Hazard (%) No. at Risk Metabolic Syndrome Yes 866 852 834 292 No 288 279 234 100 Yes 866 852 834 292 No 288 279 234 100 Follow-up (Years) Follow-up (Years) RR (85% CI) 2.13 (1.64-3.61) RR (85% CI) 3.55 (1.96-6.43) Metabolic Syndrome Yes No Metabolic Syndrome Yes No
Background image of page 4
March 8, 2012 5
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
March 8, 2012 6
Background image of page 6
March 8, 2012 7
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
March 8, 2012 8 ROLE OF PEROXISOME PROLIFERATOR- ACTIVATED RECEPTORS PPARs—Steroid hormone nuclear receptors Act as ligand-activated transcription factors Control expression of specific target genes Protein products control a variety of cellular functions PPAR-alpha family is a critical regulator of fatty acid metabolism Expressed throughout vasculature; limits adhesion molecule expression,tissue factor production PPAR-gamma family plays central role in fatty tissue production,fat metabolism,glucose regulation Highly expressed in endothelial cells,smooth muscle cells,lymphocytes,macrophages
Background image of page 8
March 8, 2012 9
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
March 8, 2012 10 PPARa regulates Apo A-I, Apo A-II, LPL, ABCA-1 and SR-BI expression
Background image of page 10
March 8, 2012 11
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 12
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 31

20261 - New Feature of NCEP ATP III:* Identification of the...

This preview shows document pages 1 - 12. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online