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Unformatted text preview: R H 2 Pd during section on carbonyls + R Cl AlCl 3 R R R note: O R R H 2 nitro group is REDUCED to AMINE Pd NO 2 NH 2 Synthesis Examples (A) + Cl AlCl 3 + + (B) + Cl AlCl 3 O O H 2 Pd (B) is better Keep in Mind Note that the Lewis acid AlCl 3 can complex with certain functional groups and kill the reaction. H H NH 2 Cl AlCl 3 Al Cl Cl N aniline Strongly e- withdrawing substituents on benzene will deactivate ring and prevent Friedel-Crafts O R Cl NO 2 AlCl 3 Alkylation may yield unexpected products (and mixtures of products) by rearrangement N.R. H H Cl AlCl 3 Cl AlCl 3 H...
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- Spring '05
- Amine, Functional group, R Cl, AlCl3 Cl Cl