bioex_lect17

bioex_lect17 - MIT OpenCourseWare http:/ocw.mit.edu 5.111...

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MIT OpenCourseWare http://ocw.mit.edu 5.111 Principles of Chemical Science Fall 2008 For information about citing these materials or our Terms of Use, visit: http://ocw.mit.edu/terms .
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Hybridization (review of material from lectures 15 and 16) See lecture 15 and lecture 16 (pages 1-2) for hybridization. Example from page 1 of Lecture 17 notes: Identifying molecules that follow the “morphine rule” Morphine, a potent and addictive analgesic (“painkiller”), and related molecules share a characteristic set of four features called the morphine rule: HC HC C H C CH H C C H 2 C C H 2 N a b 1) phenyl ring 2) _______ C 4) _______ N 3) CH 2 CH 2 1) a phenyl ring 2) an sp 3 hybridized carbon atom 3) a CH 2 -CH 2 sequence 4) an sp 3 hybridized nitrogen atom These structural elements are responsible for the bioactivity of morphine and other molecules that are pharmacologically similar to morphine. Examples are shown below with the “morphine rule” features highlighted in purple.
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This note was uploaded on 03/02/2012 for the course CHEM 5111 taught by Professor Vogel during the Fall '08 term at MIT.

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bioex_lect17 - MIT OpenCourseWare http:/ocw.mit.edu 5.111...

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