bioex_lect35

bioex_lect35 - MIT OpenCourseWare http/ocw.mit.edu 5.111...

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MIT OpenCourseWare http://ocw.mit.edu 5.111 Principles of Chemical Science Fall 2008 For information about citing these materials or our Terms of Use, visit: http://ocw.mit.edu/terms .
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Catalysts of Life: Enzymes See lecture 35 notes for an introduction to enzyme catalysis. An enzyme is a large protein molecule (typically 20,000 g/mol or more) that is capable of carrying out a specific reaction or series of reactions. Enzyme catalysis Reactant molecules are called substrates. Example from Lecture 35 video: Enzyme Catalysis An iron-containing enzyme catalyzes the final step in the biosynthesis of the antibiotic fosfomycin. The structure (shown below) of this enzyme step was reported by the Drennan laboratory at MIT in 2005. H 3 C H 3 C PO 3 H 2 CH CH 2 HC CH HO PO 3 H 2 O reactant fosfomycin (an antibiotic) substrate (S) product (P) Enzyme (E) With the emergence of antibiotic-resistant bacteria, the development of new antibiotics will be an important problem for future chemists to tackle. Substrates bind to an active site on the enzyme.
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bioex_lect35 - MIT OpenCourseWare http/ocw.mit.edu 5.111...

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