bioex_lect36 - MIT OpenCourseWare http/ 5.111...

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MIT OpenCourseWare 5.111 Principles of Chemical Science Fall 2008 For information about citing these materials or our Terms of Use, visit: .
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36.1 Review of Lecture 19-36 Topics: The Methionine Synthase Case Study See lecture 36 video for more details and to fill in the blanks for these examples. Review of Topics Chemical Equilibrium, Acid Base, Oxidation Reduction, Transition Metals, and Kinetics These topics represent the basic principles of how enzymes work, and one needs to understand how enzymes work to inhibit them. Inhibition of enzymes is used to treat headaches, arthritis, cancer, HIV, etc Big money for the Pharmaceutical industry Let's review these topics using methionine synthase as a case study. KINETICS Methionine synthase (MetH) is an enzyme, "a catalyst of life". It transfers a methyl group from methyltetrahydrofolate to homocysteine, generating methionine and tetrahydrofolate. Inhibition of this enzyme has been associated with neutral tube defects and heart disease. It is also a
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This note was uploaded on 03/02/2012 for the course CHEM 5111 taught by Professor Vogel during the Fall '08 term at MIT.

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bioex_lect36 - MIT OpenCourseWare http/ 5.111...

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