L1to9Bio_Key

# L1to9Bio_Key - MIT OpenCourseWare http/ocw.mit.edu 5.111...

This preview shows pages 1–3. Sign up to view the full content.

MIT OpenCourseWare http://ocw.mit.edu 5.111 Principles of Chemical Science Fall 2008 For information about citing these materials or our Terms of Use, visit: http://ocw.mit.edu/terms .

This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document
5.111 Principles of Chemical Science Solutions to selected biology-related questions from problem sets for lectures 1-9 Review of fundamentals A. Lisinopril, sold under the brand names of Prinivil ® (Merck) or Zestril (AstraZeneca), is a small molecule drug used to treat high blood pressure and heart failure. It works by inhibiting the production of angiotensin, a signaling molecule found in the blood that causes vasoconstriction (narrowing of blood vessels) and increased blood pressure. Lisinopril has a mass percentage composition of 62.2% carbon, 7.7% hydrogen, and 10.4% nitrogen, with the balance being oxygen. What is the empirical formula of lisinopril? Molecular weight of C 6 H 12 O 6 = 180.16 400. g C 6 H 12 O 6 x 1 mol = 2.22 0 mol of C 6 H 12 O 6 180.16 g C 6 H 12 O 6 2.22 0 mol of C 6 H 12 O 6 x 6 mol O 2 = 13.3 2 mol O 2 1 mol C 6 H 12 O 6 13.3 2 mol O 2 x (32.00 g / mol) = 426 .2 g amount of O in Lisinopril = 100.0 g – 62.2 g – 7.7 g – 10.4 g = 19.7 g of O We can now fill in the table to calculate the molar ratios: element amt. in 100 g lisinopril # of moles molar ratios (x 3) C 62.2 g 62.2 g/(12.01 g mol -1 ) = 5.17 9 mol 6.97 7 (20.9 3) H 7.7 g 7.7 g/(1.0079 g mol -1 ) = 7.64 mol 10.3 (30.9) N 10.4 g 10.4 g/(14.01 g mol
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

### Page1 / 5

L1to9Bio_Key - MIT OpenCourseWare http/ocw.mit.edu 5.111...

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document
Ask a homework question - tutors are online