L10to20Bio

L10to20Bio - MIT OpenCourseWare http:/ocw.mit.edu 5.111...

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MIT OpenCourseWare http://ocw.mit.edu 5.111 Principles of Chemical Science Fall 2008 For information about citing these materials or our Terms of Use, visit: http://ocw.mit.edu/terms .
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5.111 Principles of Chemical Science Selected biology-related questions from problem sets for lectures 10-20 Electron configurations A. A class of enzymes called the cytochromes P450 are found in the liver. These important enzymes catalyze the oxidation of small molecules (such as drugs) to enable excretion from the body. Person-to-person variations in the amounts of certain cytochrome P450 enzymes can account for drastic differences in the way individuals respond to the same dosage of a drug. Like many enzymes, cytochrome P450 enzymes require association with metal atoms for activity. Specifically, the oxidation of target molecules by cytochromes P450 requires iron. (a) Give the electron configuration of neutral iron. Provide the electron configuration for the following iron ions. Iron in its +2, +3, and +4 oxidation state are all involved in cytochrome P450 catalysis. (b) Fe
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This note was uploaded on 03/02/2012 for the course CHEM 5111 taught by Professor Vogel during the Fall '08 term at MIT.

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L10to20Bio - MIT OpenCourseWare http:/ocw.mit.edu 5.111...

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