L21to26Bio

L21to26Bio - MIT OpenCourseWare http:/ocw.mit.edu 5.111...

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
MIT OpenCourseWare http://ocw.mit.edu 5.111 Principles of Chemical Science Fall 2008 For information about citing these materials or our Terms of Use, visit: http://ocw.mit.edu/terms .
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
5.111 Principles of Chemical Science Selected biology-related questions from problem sets for lectures 21-26 Acid-base problems A. A pharmaceutical molecule with antifungal properties is only active when deprotonated and negatively charged (A - ). The protonated state (HA) is inactive. If the pK a of this drug is 10.0, (a) calculate the ratio of protonated to deprotonated compound at physiological pH (7.4). ( b ) Is this drug likely to be a useful pharmaceutical agent? B. Absorption of aspirin (acetylsalicylic acid, C 9 H 8 O 4 ,) into the bloodstream occurs only when the molecule is in its conjugate base form. (a) If a patient takes two tablets of aspirin (325 mg each), how many grams of aspirin are available for immediate absorption in the stomach? The pH of the stomach is 1.6, and the pK a of aspirin is 3.5.
Background image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 03/02/2012 for the course CHEM 5111 taught by Professor Vogel during the Fall '08 term at MIT.

Page1 / 3

L21to26Bio - MIT OpenCourseWare http:/ocw.mit.edu 5.111...

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online