Lect2 - 1 Lecture 2 Glycolysis 2 How to study metabolism...

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Unformatted text preview: 1 Lecture 2 Glycolysis 2 How to study metabolism • Overall reaction • Key metabolites (i.e. reactants, products and intermediates) • Key mechanisms • Regulation (i.e., rate-determining steps and key enzymes) • Chemical logic behind pathways 3 Important concepts 1. All metabolites involved in the pathway 2. Enzymes and their function and regulation 3. Balance sheet of ATP 4. Mechanism: aldolase 5. NADH 4 General Features:Compartments Oxidative Phosphorylation — mitochondrion Glycolysis — cytoplasm Compartments, therefore transport required Plant Cell Animal Cell 5 • Glucose enters cell through glucose transporters • Or, glucose from breakdown of polysaccharides (glycogen from liver, dietary starches) • Or, glucose from biosynthesis (gluconeogenesis) from noncarbohydrate precursors Where does the glucose come from? 6 Glucose (6 carbons) converted to two molecules of pyruvate (3 carbons) and 2 molecules of ATP (energy capture), with 2 molecules of NAD + reduced to NADH, in 10 reactions....
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This note was uploaded on 03/04/2012 for the course CHEM 114B taught by Professor Wang during the Spring '09 term at UCSD.

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Lect2 - 1 Lecture 2 Glycolysis 2 How to study metabolism...

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