Lect4(1)

Lect4(1) - Lecture 4 Gluconeogenesis 1 Blood glucose level...

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1 Lecture 4 Gluconeogenesis
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2 Lehninger, Fig. 23-11 Blood glucose level is critical
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3 Important concepts 1. Memorize non-carbohydrate precursors, where to enter the pathway Cori cycle 2. Memorize all metabolites and enzymes (difference with glycolysis) Biotin Malate shuttle Small molecule structure (<6 carbon) Balance sheet for ATP and NADH 3. Understand and memorize regulatory steps and mechanisms
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4 Gluconeogenesis • Covert pyruvate to glucose Mostly in liver, some in kidney • Non-carbohydrate precursors Lactate Most amino acids, except Leu and Lys Glycerol ! Not fatty acids in animals In animal, no conversion from Acetyl-CoA to oxaloacetate Cori Cycle
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5 Lactate converted to pyruvate
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6 Glycerol converted to DHAP
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7 GAPDH PG kinase PG mutase Enolase Pyruvate Kinase Hexokinase PFK Aldolase TIM Glycolysis: How do you go backwards? Principle: Breakdown and synthesis have key steps that are different
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8 Reactions of glycolysis Note difference between ’ and G Why the difference?
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9 Pyruvate set to 0 -22
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10 Glycolysis vs. gluconeogenesis mitochondrion cytosal
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11 Important concepts 1. Non-carbohydrate precursors, where to enter the pathway Cori cycle 2. All metabolites and enzymes (difference with glycolysis) Biotin Malate shuttle Small molecule structure (<6 carbon) Balance sheet for ATP and NADH 3. Regulatory steps and mechanisms
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This note was uploaded on 03/04/2012 for the course CHEM 114B taught by Professor Wang during the Spring '09 term at UCSD.

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Lect4(1) - Lecture 4 Gluconeogenesis 1 Blood glucose level...

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