Lect9 - Lecture 9 Oxidative Phosphorylation (III) 0...

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0 Lecture 9 Oxidative Phosphorylation (III)
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1 Important concepts 1. Understanding transporting metabolites in and out of mitochondrial Glycerol-3-phosphate shuttle Malate-aspartate shuttle Their implication for ATP equivalent of NADH 2. Understand regulation of oxidative phosphorylation Inhibit electron transfer Inhibit ATP synthase Uncoupling electron transport from ATP synthesis Inhibit ATP export
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2 Inner Membrane Outer Membrane Cytosol H + Cytosol Mitochondrion Cristae Matrix Intermembrane space Outer membrane: permeable to most small molecules Inner membrane: impermeable to … Many shuttles allow movement across the mitochodrial membranes
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3 Electrons from cytoplasmic NADH: glycerol 3-phosphate shuttle Inner mitochondrial membrane is impermeable to NADH and NAD + Less ATP generated (NADH=1.5 ATP) Glycerol 3-phosphate shuttle is prominent in muscle
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Glycolysis 2 ATP 2 NADH = 3 ATP Pyruvate Deydrogenase 2 NADH = 5 ATP Citric Acid Cycle 6 NADH = 15 ATP 2 FADH 2 = 3 ATP 2 GTP = 2 ATP See Table 18.4 Total = 5 ATP Total = 20 ATP Balance Sheet Energy NADH = (2.5 ATP) FADH 2 = (1.5 ATP) GTP = (ATP) Total = 5 ATP Total = 30 ATP glycerol 3-phosphate shuttle
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5 Electrons from cytoplasmic NADH: Malate-aspartate shuttle transporters exist for malate and aspartate oxidize NADH in cytoplasm and reduce NAD + in matrix, one NADH is effectively transported into the matrix malate-aspartate shuttle is prominent in heart and liver
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6 Malate shuttle transports oxaloacetate to cytoplasm
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Glycolysis 2 ATP 2 NADH = 5 ATP Pyruvate Deydrogenase 2 NADH = 5 ATP Citric Acid Cycle 6 NADH = 15 ATP 2 FADH 2 = 3 ATP 2 GTP = 2 ATP
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This note was uploaded on 03/04/2012 for the course CHEM 114B taught by Professor Wang during the Spring '09 term at UCSD.

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Lect9 - Lecture 9 Oxidative Phosphorylation (III) 0...

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