Lect13 - 1 Lecture 13 Pentose Phosphate Pathway 2 Important...

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Unformatted text preview: 1 Lecture 13 Pentose Phosphate Pathway 2 Important concepts 1. Memorize the intermediates of pentose phosphate pathway Understand how to make 6C and 3C from 5C And understand the mechanism Balance sheet 2. Understand regulation of pentose phosphate pathway Regulation on oxidation (NADP+ activates G6PD) Regulated by the need of the intermediates 3. Understand how NADPH removes reactive oxygen species (ROS) 3 Pentose Phosphate Pathway Required for generation of NADPH Also produces Ribose-5-phosphate (R5P) for nucleotide biosynthesis 4 Compartments Pentose phosphate Pathway — cytoplasm 5 NAD + NADP + Capture energy from metabolism Capture energy from metabolism For ATP generation through oxidative phosphorylation For reductive biosynthesis (fatty acids and cholesterol) NAD + /NADH 1000/1(favors metabolite oxidation) NADP + /NADPH 1/100 (favors reductive biosynthesis) Selective dehydrogenases Selective dehydrogenases 6 Pentose Phosphate Pathway Where does glucose 6- phosphate come from? 7 8 First step of glycolysis — Hexokinase First step: Getting a phosphate on carbon #6. PO 3 2- ATP + + ADP + H + Glucose Glucose-6- phosphate (G6P) 9 Instead of second step of glycolysis, Phosphoglucose Isomerase Use Glucose-6- phosphate dehydrogenase 9 Pentose Phosphate Pathway: Phase 1 Oxidation: electron acceptor NADP + Glucose 6-posphate dehydrogenase specific for NADP + 10 Pentose Phosphate Pathway: Phase 1 Oxidation: electron acceptor NADP + Hydrolysis 11 Pentose Phosphate Pathway: Phase 1...
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This note was uploaded on 03/04/2012 for the course CHEM 114B taught by Professor Wang during the Spring '09 term at UCSD.

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Lect13 - 1 Lecture 13 Pentose Phosphate Pathway 2 Important...

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