Lect15 - Lecture 15 Glycogen synthesis 1 Important concepts 1 Understand glycogen synthesis Understand the process(UDP-glucose growth of glycogen

Info iconThis preview shows pages 1–10. Sign up to view the full content.

View Full Document Right Arrow Icon
1 Lecture 15 Glycogen synthesis
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2 Important concepts 1. Understand glycogen synthesis Understand the process (UDP-glucose, growth of glycogen, branching) Understand glycogen starts with glycogenin 2 ATP/glucose added to glycogen 2. Understand regulation of glycogen synthesis (glycogen synthase) Allosteric regulation (activated by G6P) Hormone regulation (muscle vs. liver)
Background image of page 2
3 Glycogen Synthesis: Thermodynamically Unfavorable Glycogen Breakdown Principle: Breakdown and synthesis have key steps that are different
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
4 Phosphoglucomutase Reversible reaction
Background image of page 4
5 UDP-glucose Pyrophosphorylase: Activating glucose-1-phosphate From phosphoglucomutase UDP-sugars used frequently, as in glycosylation of proteins
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
6 UDP-glucose Pyrophosphorylase: Activating glucose-1-phosphate through a coupled reaction From phosphoglucomutase Coupled Reactions
Background image of page 6
7 Coupled Reactions Coupling UDP-glucose pyrophosphorylase to inorganic pyrophosphatase
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
8 Glycogen Synthesis
Background image of page 8
UDP good leaving group - activation of glucose 4 1 4 UDP-Glucose + Glycogen n UDP + Glycogen n+1 Glycogen Synthase
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 10
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 03/04/2012 for the course CHEM 114B taught by Professor Wang during the Spring '09 term at UCSD.

Page1 / 31

Lect15 - Lecture 15 Glycogen synthesis 1 Important concepts 1 Understand glycogen synthesis Understand the process(UDP-glucose growth of glycogen

This preview shows document pages 1 - 10. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online