Lect16 - Lecture 16 Metabolism of Fatty Acids 1 Important...

Info iconThis preview shows pages 1–12. Sign up to view the full content.

View Full Document Right Arrow Icon
1 Lecture 16 Metabolism of Fatty Acids
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2 Important concepts 1. Understand the basics of triacylglycerols Understand the structure Highly condensed energy fuel Understand the digestion and transportation of dietary lipids 2. Understand breakdown of triacylglycerols Glycerol -> glycolysis/gluconeogenesis Fatty acids -> acyl-CoA -> citric acid cycle 3. Understand and memorize β oxidation Balance sheet Saturated vs. unsaturated Even vs. odd number of carbons Ketone bodies
Background image of page 2
3 What are fats? Triacyl glycerols
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
4 Fuel molecules, stored as triacylglycerols Building blocks of phospholipids and glycolipids Covalent attachment of fatty acids to proteins – target to membrane Fatty acid derivatives serve as hormones and intracellular messengers Physiological roles of fatty acids
Background image of page 4
5 More reduced than carbohydrates and proteins complete oxidization of fatty acids ~ 38 kJ/gram carbohydrates ~ 17kJ/gram Triacylglycerols are hydrophobic - condense same energy stored in 11 kg triacylglycerols = 75 kg glycogen • In mammals, triacylglycerols stored in adipose (fat) cells Triacylglycerols: highly condensed energy stores Fuel golden plover’s migration of 2400 miles
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
6 Mirror reactions
Background image of page 6
7 Dietary Lipids are digested by lipases Triacylglycerol lipase catalyzes hydrolysis of triacylglycerol -> produce mono- or diacylglycerols Lipase is secreted by the pancreas Absorption aided by bile acids to increase solubility of triacylglycerol
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
8 Fatty Acids hydrophobic (not soluble in water) Bile acids (salts) — amphipathic (wrap around fats) Cholesterol derivatives synthesized by liver Stored in gallbladder Secreted into small intestine for absorption Also for absorption of lipid-soluble vitamins (A, D, E, K) Solubilization of Fats
Background image of page 8
9 bloodstream Degraded or stored in adipose tissues & muscle Dietary Lipids are transported in chylomicrons
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
10 Important concepts 1. Understand the basics of triacylglycerols Understand the structure Highly condensed energy fuel Understand the digestion and transportation of dietary lipids 2. Understand breakdown of triacylglycerols Glycerol -> glycolysis/gluconeogenesis Fatty acids -> acyl-CoA -> citric acid cycle 3. Understand and memorize β oxidation Balance sheet Saturated vs. unsaturated Even vs. odd number of carbons Ketone bodies
Background image of page 10
11 Three stages of utilizing fatty acids energy Lipids become mobilized - broken down to fatty acids and
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 12
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 03/04/2012 for the course CHEM 114B taught by Professor Wang during the Spring '09 term at UCSD.

Page1 / 62

Lect16 - Lecture 16 Metabolism of Fatty Acids 1 Important...

This preview shows document pages 1 - 12. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online