Lect17 - Lecture 17 Fatty Acid Metabolism (II) 1 2...

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Unformatted text preview: Lecture 17 Fatty Acid Metabolism (II) 1 2 Important concepts 1. Understand synthesis of fatty acids Difference between degradation and synthesis Balance sheet 2. Understand the regulation of fatty acids metabolism Regulation on synthesis: Acetyl CoA carboxylase (phosphorylation; citrate; hormone) Regulation on degradation: malonyl CoA Fatty Acid Biosynthesis: Condensation of C2 units Konrad Bloch 1912-2000 Nobel Prize in Physiology or Medicine, 1964 David Rittenberg 1906-1970 3 4 Catabolic and Anabolic Differ 5 Acetyl-CoA at the crossroads Fatty Acid Oxidation Pyruvate Demand for Energy High Citric Acid Cycle and Oxidative Phosphorylation Demand for Energy Low Fatty Acid Synthesis 6 CH 3-C ~ O How do you go from here to there? First, you have to get Acetyl-CoA from the mitochondrion to the cytosol Acetyl-CoA 7 Transfer of acetyl CoA to the cytoplasm: Tricarboxylate Transport System 8 See reference slides for details Catabolic and Anabolic Differ 9 Malonyl-CoA (3 carbons) from Acetyl-CoA (2 carbons) Use ATP to activate CO 2 CO 2 activation followed by carboxylation Biotin cofactor (similar to pyruvate carboxylase and propionyl CoA carboxylase ) Acetyl-CoA Carboxylase 10 CO 2 Biotin: Cofactor for carboxylations 11 Catabolic and Anabolic Differ Acyl Carrier Protein 12 Acyl Carrier Protein Growing fatty acid linked to a Serine residue in acyl-carrier protein (ACP) a giant CoA Part of Fatty Acid Synthase 13 Step #1: Priming Acyl Carrier Protein and Transacylases are components of fatty acids synthase complex nzyme 14...
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Lect17 - Lecture 17 Fatty Acid Metabolism (II) 1 2...

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