Lect19 - Lecture 19 Amino Acid Breakdown 2 Important concepts 1 Understand Urea cycle Memorize the intermediates Memorize the location of the

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Unformatted text preview: Lecture 19 Amino Acid Breakdown 2 Important concepts 1. Understand Urea cycle Memorize the intermediates Memorize the location of the reactions Treat diseases caused by deficient enzymes 2. Understand degradation of carbon atoms Memorize the degraded metabolites Oxygenase is required for breakdown of aromatic ring 4 Urea Cycle: release nitrogen 5 1. Carbamoyl Phosphate Synthetase • ATP activates HCO 3- • NH 3 attacks, releasing Pi • NH 3 normally exists as NH 4 + , but synthetase only recognizes NH 3 • irreversible reaction (consumption of 2 ATPs) 6 2. Ornithine Transcarbamoylase Like Arg • Loss of Pi 3. Argininosuccinate Synthetase • Back in the cytosol • Addition of second amino group NH 3 (from Asp ) • ATP used, driving the reaction • PP i rapidly hydrolyzed, equivalent to 2 ATP Arg succinate 4. Argininosuccinase • carbons of aspartate are conserved in fumarate 9 Comparison: Oxidation of succinate to regenerate oxaloacetate in CAC oxidation oxidation hydration 10 5. Arginase • Yield urea to be excreted • Regenerate ornithine for further cycles 5. Arginase • Yield urea to be excreted • Regenerate ornithine and transported into mitochondrion for further cycles 12 Fumarate reconverted to Asp • Fumarase and Malate dehydrogenase — citric acid cycle but in cytosol • Transamination • Or oxaloacetate to gluconeogenesis 13...
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This note was uploaded on 03/04/2012 for the course CHEM 114B taught by Professor Wang during the Spring '09 term at UCSD.

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Lect19 - Lecture 19 Amino Acid Breakdown 2 Important concepts 1 Understand Urea cycle Memorize the intermediates Memorize the location of the

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