Lect24 - Lecture 24 Lipids and Steroids Biosynthesis 1...

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Lecture 24 Lipids and Steroids Biosynthesis 1
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2 Lipids synthesis Triacylglycerol Phospholipids: Glycerolipids (most abundant phospholipids) Sphingolipids (enriched in nervous system) Cholesterol
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3 Important concepts 1. Understand the synthesis of Triacylglycerol 2. Understand the regulation of Phospholipids Synthesis of glycerol lipids Phospholipids synthesis starts with activated phosphatidate by CTP Phospholipids synthesis starts with activated alcohol by ATP and CTP Synthesis of sphingolipids 3. Understand the synthesis of Cholesterol Memorize how HMG-CoA forms the 5C building block isoprene Understand the condensation of 5C to 30C squalene Understand the important role of NADPH
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4 Phospholipids and triacylglycerol synthesis
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5 Common Intermediate of Phospholipids and triacylglycerol synthesis Diacyl-glycerol-3-phosphate Catalyzed by glycerol phosphate acyltransferase In most phosphatidates, R1=saturated fatty acids, R2=unsaturated fatty acids
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6 Triacylglycerol synthesis Catalyzed by two enzymes in a triacylglyerol synthetase complex The synthetase complex bound to the endoplasmic reticulum membrane synthesized in liver , then to muscle or adipose tissues Diacylglycerol acyltransferase phosphatase
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7 Important concepts 1. Understand the synthesis of Triacylglycerol 2. Understand the regulation of Phospholipids Synthesis of glycerol lipids Phospholipids synthesis starts with activated phosphatidate by CTP Phospholipids synthesis starts with activated alcohol by ATP and CTP Synthesis of sphingolipids 3. Understand the synthesis of Cholesterol Memorize how HMG-CoA forms the 5C building block isoprene Understand the condensation of 5C to 30C squalene Understand the important role of NADPH
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8 Lipids synthesis Triacylglycerol Phospholipids: Glycerolipids (most abundant phospholipids) Sphingolipids (enriched in nervous system) Cholesterol
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This note was uploaded on 03/04/2012 for the course CHEM 114B taught by Professor Wang during the Spring '09 term at UCSD.

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Lect24 - Lecture 24 Lipids and Steroids Biosynthesis 1...

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