HW2addendum - carbonyl oxygen Problem 3 Focus on the...

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CH223-001/003 Spring 2012 Homework 2 Addendum Problem 1: You need to use nucleophilic aromatic substitution to introduce the OH group. Problem 2: First part – correct product is You can generate an acylium ion from the ester by first protonating the non-
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Unformatted text preview: carbonyl oxygen. Problem 3: Focus on the regiochemistry with regard to the position of tryptophan that gets alkylated. Assume the allyl group will preferentially react at the primary carbon for steric reasons. OH H 3 C O...
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