lec25 - Biochemistry I Fall Term 2004 November 5 2004...

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1 Biochemistry I Fall Term, 2004 November 5, 2004 Lecture 25: Membrane Transport Assigned reading in Campbell: Chapter 7.6 Key Terms: Uniport Symport Antiport Gated pore mechanism Glucose permease Lactose permease Na + -K + pump Links : ( I ) Review Quiz on Lecture 25 concepts ( I ) Lactose Permease : Flash animation of the mechanism ( I ) Na + -K + Pump : Part of the Flash animation on membranes ( S ) Lactose Permease : Structure of the inward-facing conformation Chime page (92K). Membrane channels were cited in the 2003 Nobel Prize for Chemistry. Potassium channel, e.g. KcsA: K + ions are transported rapidly; Na + ions are not. Aquaporins, e.g. Water channels: 11 related proteins in mammals. Classes of Integral Membrane Transporters 1. Uniport : a single molecule (or ion) is transported (in or out) Example: glucose permease of the red blood cell. (facilitated diffusion) Reaction scheme: E 2 E 2 (U) E 1 E 1 (U) U (in) U (out)
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2 2. Symport : two different molecules (or ions) are transported in the same direction.
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lec25 - Biochemistry I Fall Term 2004 November 5 2004...

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