lec31 - Biochemistry I Fall Term, 2004 November 22 &...

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1 Biochemistry I Fall Term, 2004 Lecture 31: Citric Acid Cycle Assigned reading in Campbell: Chapter 16 Key Terms: Amphibolic Anaplerotic Nonheme iron protein Oxidative decarboxylation Malate shuttle Mitochondrial structure: Matrix Christae Links : ( I ) Review Quiz on Lecture 31 concepts ( I ) Citric Acid Cycle Summary Class handout on the reactions in the pathway. ( S ) Metabolic Pathway Simulation and the effects of an inhibitor. ( S ) Citric Acid Cycle Intermediates Chime images of the reactions in the pathway. Some General Features Sir Hans Krebs, who won a Nobel Prize for its discovery, preferred the term "tricarboxylic acid cycle" (TCA cycle). The enzymes that participate in the citric acid cycle are found in the mitochondrial matrix. The pathway is amphibolic, i.e. the reactions are involved in catabolic (breakdown) and anabolic (biosynthesis) processes. In contrast to glycolysis, none of the intermediates are phosphorylated; but all are either di- or tricarboxylic acids. In contrast to the elaborate allosteric regulation of glycogen metabolism, most of the regulation is provided by substrate availability and product inhibition.
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2 Four Key Enzymes in the Citric Acid Cycle
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This note was uploaded on 03/04/2012 for the course BIOCHEM 451 taught by Professor Clavijo during the Spring '06 term at Carnegie Mellon.

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lec31 - Biochemistry I Fall Term, 2004 November 22 &...

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