lec32 - Biochemistry I Fall Term, 2004 December 3 & 6,...

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1 Biochemistry I Fall Term, 2004 Lecture 32: Oxidative Phosphorylation Assigned reading in Campbell: Chapter 17 Key Terms: ATP synthase Chemiosmotic coupling Coenzyme Q (CoQ <=> CoQH 2 ) Membrane potential Proton gradient P/O ratios Links : ( I ) Review Quiz on Lecture 32 concepts ( I ) ATP Synthesis : Flash tutorial of the FoF1 ATP synthase ( S ) Synthesis of ATP from the Proton Gradient : animation of the FoF1 ATP synthesis cycle. ( S ) ATP Synthase : Overall architecture of the FoF1 complex (Chime). ( O ) ATP Synthase : A detailed lecture by Antony Crofts, University of Illinois. (Be sure to watch the movie of the rotating F1 ATPase.) The overall reactions are: 1. O 2 + 4 H + + 4e - --> 2 H 2 O 2. nADP + nP i --> nATP Four Key Complexes in Electron Transport The following complexes are localized to the inner mitochondrial membrane. Complex I : NADH-CoQ oxidoreductase An integral membrane protein complex. Contains flavin mononucleotide (FMN) covalently attached to proteins; also contains iron-sulfur proteins. Two electrons from NADH are transferred to Coenzyme Q (CoQ). a. CoQ is mobile within the inner membrane. b. Cycles between CoQ <=> CoQH 2 . Two protons are pumped from the inside (matrix) to the intermembrane space.
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2 Complex II : Succinate-CoQ oxidoreductase An integral membrane protein complex. Succinate dehydrogenase of the citric acid cycle is part of this complex.
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This note was uploaded on 03/04/2012 for the course BIOCHEM 451 taught by Professor Clavijo during the Spring '06 term at Carnegie Mellon.

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lec32 - Biochemistry I Fall Term, 2004 December 3 &amp; 6,...

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