Dec01 - DECEMBER 11T H 2001 TERM EXAMINATION - BIO250Y1Y...

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DECEMBER 11 TH 2001 TERM EXAMINATION - BIO250Y1Y Answers: a,c,b,c,e,e,e,e,d,d,e,c,d,d,e,a,c,b,d,a,c,c,a,c,e,b,a,a,c,d,d,a,b,b,b,a,a,c,b,b,b,c,c,b,b,c,e,d,a,b,d,e,b,a,b,e,d,a ,a,e,c,a,d,b,d,a,d,a,b,c Lecture questions 1 through 50: 1) The sequence of one strand of a DNA fragment is: 5'ATGCGTGACTAATTCG3' Which of the following is the CORRECT double-stranded sequence? a) 5'-ATGCGTGACTAATTCG-3' 3'-TACGCACTGATTAAGC-5' b) 5'-ATGCGTGACTAATTCG-3' 5'-TACGCACTGATTAAGC-3' c) 5'-ATGCGTGACTAATTCG-3' 3'-TUCGCUCTGUTTUUGC-5' d) 5'-ATGCGTGACTAATTCG-3' 3'-ATGGCACTGATTAAGC-5' e) 5'-ATGCGTGACTAATTCG-3' 3'-UACGCACUGAUUAAGC-5' 2) How many amino acids would be in the protein encoded by a gene with the sequence 3' TACCCGGATTCA 5'? a) 1 b) 2 c) 4 d) 6 e) 12 3) Given the following DNA template strand: 3'-GCTTAATCAGTGCGTA-5' Which of the following is the CORRECT sequence of the RNA transcript? a) 3'-CGAAUUAGUCACGCAU-5'. b) 5'-CGAAUUAGUCACGCAU-3'.
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2 c) 5'-CGAATTAGTCACGCAT-5'. d) 3'-CGAATTAGTCACGCAT-5'. e) 5'-pppCGAATTAGTCACGCAT-3'. 4) You have a polypeptide containing this sequence of amino acids: His-Met-Leu-Ile-Lys. Using the mRNA genetic code for amino acids listed below, choose the DNA template sequence that corresponds to this polypeptide. mRNA codon amino acid UUA Leu AUU Ile AUC AUA Met AUG CAC His CAU AAA Lys A DNA template sequence for this polypeptide could be a) 3'GUGUACAAUAUUUUU5'. b) 3'GTGTACAATATTTTT5'. c) 3'GTATACAATTAATTT5'. d) 3'GUAUACAAUUAUUUU5'. e) 3'CAUAUGUUAAUAAAA5' 5) Which one of the following anticodon and codon pairs is not normally observed in vivo ? a) 3' UAC 5' tRNA 5' AUG 3' mRNA b) 3' GAI 5' tRNA 5' CUC 3' mRNA c) 3' GAI 5' tRNA 5' CUU 3' mRNA } }
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3 d) 3' AUA 5' tRNA 5' UAU 3' mRNA e) 3' UAC 5' tRNA 5' AUU 3' mRNA 6) For translation to proceed in E. coli , which of the following must occur? 1. The Shine-Delgarno sequence of the mRNA binds the 3'-end complementary 16S RNA sequence. 2. The anticodon UAC binds to the AUG codon at the P site of the ribosome. 3. A tRNA carrying an appropriate amino acid binds to the A site of the ribosome. 4. Peptide bond formation occurs between the amino acid in the P site and the second amino acid in the A site. 5. Translocation of the mRNA one codon length through the ribosome, bringing the newly formed peptidyl tRNA to the P site. a) 2, 4, 5 b) 1, 2, 3, 4 c) 1, 3, 5 d) 3, 4, 5 e) 1, 2, 3, 4, 5 7) During formation of the bacterial 70S protein initiation complex, which of the following are CORRECT? 1. The 30S ribosomal subunit binds three initiation factors IF1, IF3 and IF2-GTP. 2. The pre-initiation complex binds mRNA and the initial tRNA carrying methionine, and IF3 is released. 3. The 30S initiation complex is composed of mRNA, IF1, IF2-GTP, tRNA with methionine, and the 30S ribosome subunit. 4. Binding of the 50S ribosome subunit with the 30S initiation complex releases IF1, IF2-GDP
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This note was uploaded on 03/04/2012 for the course BIOM 426 taught by Professor Staff during the Fall '08 term at WVU.

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Dec01 - DECEMBER 11T H 2001 TERM EXAMINATION - BIO250Y1Y...

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