lec-21 - CS70: Satish Rao: Administration. 1. Midterm...

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Unformatted text preview: CS70: Satish Rao: Administration. 1. Midterm regrades requests due by your section. CS70: Satish Rao: Lecture 21. 1. PSA discussion. 2. Checksums. 3. Coupon Collectors Problem. Consequences of PSA Treatment. The most common are impotence and incontinence. The adverse consequences of not acting upon this bad news, on the other hand, are more existential than lethal. Men who are informed of a positive PSA-screen for prostate cancer, but elect to do nothing, live usually until their mid-70s or beyond with the negative psychological burden of believing they have a cancer diagnosis they either do not in fact have (false positive) or they do in fact have a slow-growing cancer that will most likely not be their ultimate cause of death (overdiagnosis). As a New York Times Magazine story noted recently, far more men will die with prostate cancer than from it, and only a tiny fraction of prostate cancers ever cause symptoms, much less death. Urological Society... Of course, this parade of horrible possibilities must be balanced against the potential for early detection and successful life-prolonging, cancer-fighting interventions. Anecdotally, such success stories are out there. In fact, the American Urological Association continues to recommend that PSA screening should be offered to men aged 40 years or older. Risks..of doing nothing. Men and their doctors need to decide for themselves. But the Task Forces review of all the published, peer-reviewed evidence, including two large studies in Europe and the United States, found no statistically significant reduction in prostate cancer deaths can be attributed to PSA-screening. It turns out that the vast majority of men (as many as 90 percent) currently treated with surgery or radiotherapy for PSA-detected prostate cancer in the U.S. do not in fact have prostate cancer death prevented or lives extended from their treatment. Yet 90 percent of them are subjected to the significant harms... Why? Larry Churchill, professor at the Center for Biomedical Ethics and Society at Vanderbilt University, noted that the Task Forces findings were not terribly surprising, given the structure of our health care system. Any society which pays its physicians by the procedure, with larger financial rewards for more invasive procedures, Churchill said, should expect an epidemic of over-diagnosis and over-treatment, some of it dangerous. Lies, damn lies, and statistics... Lies, damn lies, and statistics... Perhaps statistics is... Lies, damn lies, and statistics... Perhaps statistics is... a remedy. Back to Computer Science.. Checksums! Given two random files; Checksums! Given two random files; Chance have same checksum? Checksums!...
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lec-21 - CS70: Satish Rao: Administration. 1. Midterm...

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