14D_w10_finalB

14D_w10_finalB - Chemistry 14D Winter 2010 Final Exam Part...

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Chemistry 14D Winter 2010 Final Exam Part B Page 1 Page 1 score = Sulfanilamide exerts it antibiotic effect by reacting with dihydropteridine diphosphate as shown below. The product of this reaction inhibits an enzyme necessary for bacterial folic acid synthesis and subsequent growth. N N N N O P O OH O P O OH + OH OH H 2 N H NH 2 S O O NH 2 N N N N N H OH H 2 N H S O O NH 2 + HO P O OH O P O OH OH Dihydropteridine diphosphate Sulfanilamide Diphosphate Questions 1–4 refer to diphosphate ion, a leaving group in a wide range of biological reactions. O P O OH O P O OH OH Diphosphate ion 1. (3) Define “leaving group.” 2. (2) As a leaving group, diphosphate is (circle one): good bad never leaves 3. (4) List two distinctly different features of diphosphate ion that influenced your thinking in question 2. Feature #1 ( fifteen words or less ) : Feature #2 ( fifteen words or less ) : 4. (3) By adding, subtracting, or transmuting no more than three atoms , rewrite the structure of diphosphate ion to make it an obviously worse leaving group. Include all lone pairs and formal charges.
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This note was uploaded on 03/12/2012 for the course CHEM 14D taught by Professor Hardinger during the Winter '08 term at UCLA.

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14D_w10_finalB - Chemistry 14D Winter 2010 Final Exam Part...

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