Chapter 17.pe - Chapter 17 Immune Modulators Copyright 2008...

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Copyright  ©  2008 Lippincott Williams & Wilkins. Chapter 17 Immune Modulators
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Copyright  ©  2008 Lippincott Williams & Wilkins. Sites of Actions of Immune Modulators  Immune modulators Modify the actions of the immune system Immune stimulants  Energize the immune system when it needs help  fighting a specific pathogen  Immune suppressants  Block the normal effects of the immune system in  organ transplantation and autoimmune disorders
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Copyright  ©  2008 Lippincott Williams & Wilkins. Immune Stimulants Interferons Naturally released from human cells in response to viral  invasion Interleukins Communicate between lymphocytes, stimulate cellular  immunity, and inhibit tumor growth T and B cell modulator (levamisole)  Restores immune function and activity
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Copyright  ©  2008 Lippincott Williams & Wilkins. Interferon Actions Prevents virus particles from replicating inside other cells Stimulates interferon receptor sites on noninvaded cells to  produce antiviral proteins Inhibits tumor growth and replication Pharmacokinetics Absorbed well after subcutaneous or intramuscular  injection Broken down in the tissues Excreted in the kidneys May be teratogenic 
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Copyright  ©  2008 Lippincott Williams & Wilkins. Interferon (cont.) Contraindications Known allergy Pregnancy and lactation Use with caution in cardiac disease, myelosuppression,  and with central nervous system dysfunction Adverse reactions Lethargy, myalgia, arthralgia, anorexia, nausea,  headache, dizziness, and bone marrow depression  Drug-to-drug interactions
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Copyright  ©  2008 Lippincott Williams & Wilkins.
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