SlidesViralGeneExp_1 - Viruses Part 2 – Gene Expression...

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Unformatted text preview: Viruses Part 2 – Gene Expression 1.  Why is gene expression controlled? 2.  Challenges faced for controlling gene expression by RNA viruses - prokaryotic vs. eukaryotic viruses 3.  Strategies used by RNA viruses -  -  -  -  -  Regulated translation Polyprotein cleavage Segmented genome Alternative splicing Transcription into monocistronic mRNAs Gene Expression During Infection Different genes expressed at different points in the infection cycle. Some proteins are needed at higher concentrations than others. Gene Expression During Infection – Eukayotic Cell Latent versus Infectious Early versus late proteins DNA Viruses •  Eukaryotic dsDNA –  RNA polymerase –  Capping enzyme –  Polyadenylating enzyme •  Prokaryotic ssDNA –  Make ds DNA to make mRNA ssRNA(+) bacterial virus ssRNA(+) Prokaryotic Virus •  Translation start inaccessible due to RNA folding •  Protein inhibition of translation ssRNA(+) eukaryotic virus VPg = covalently attached viral protein Cleavage of a Polyprotein Segmented Genome ssRNA(-) eukaryotic virus Alternative Splicing ssRNA(-) virus transcription into monocistronic mRNAs ...
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This note was uploaded on 03/06/2012 for the course MIMG 100 taught by Professor Lazazzera during the Summer '10 term at UCLA.

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