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Unformatted text preview: Viruses Part 2 – Gene
1. Why is gene expression controlled?
2. Challenges faced for controlling gene
expression by RNA viruses
- prokaryotic vs. eukaryotic viruses 3. Strategies used by RNA viruses
- Regulated translation
Transcription into monocistronic mRNAs Gene Expression
Different genes expressed at
different points in the infection
Some proteins are needed at
higher concentrations than others. Gene Expression
During Infection –
Latent versus Infectious
Early versus late proteins DNA Viruses
• Eukaryotic dsDNA
– RNA polymerase
– Capping enzyme
– Polyadenylating enzyme • Prokaryotic ssDNA
– Make ds DNA to make mRNA ssRNA(+) bacterial virus ssRNA(+) Prokaryotic Virus
• Translation start inaccessible due to
• Protein inhibition of translation ssRNA(+) eukaryotic virus VPg = covalently attached viral protein Cleavage of a Polyprotein Segmented Genome ssRNA(-) eukaryotic virus Alternative Splicing ssRNA(-) virus
transcription into monocistronic mRNAs ...
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This note was uploaded on 03/06/2012 for the course MIMG 100 taught by Professor Lazazzera during the Summer '10 term at UCLA.
- Summer '10