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RNAswitchReview

RNAswitchReview - This article was downloaded by[California...

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This article was downloaded by:[California Digital Library -CDL (CRC journals only) Consortium] On: 13 November 2007 Access Details: [subscription number 758075928] Publisher: Informa Healthcare Informa Ltd Registered in England and Wales Registered Number: 1072954 Registered office: Mortimer House, 37-41 Mortimer Street, London W1T 3JH, UK Critical Reviews in Biochemistry and Molecular Biology Publication details, including instructions for authors and subscription information: http://www.informaworld.com/smpp/title~content=t713609207 From Ribosome to Riboswitch: Control of Gene Expression in Bacteria by RNA Structural Rearrangements Frank J. Grundy a ; Tina M. Henkin a a Department of Microbiology, The Ohio State University, Columbus, Ohio, USA Online Publication Date: 01 December 2006 To cite this Article: Grundy, Frank J. and Henkin, Tina M. (2006) 'From Ribosome to Riboswitch: Control of Gene Expression in Bacteria by RNA Structural Rearrangements', Critical Reviews in Biochemistry and Molecular Biology, 41:6, 329 - 338 To link to this article: DOI: 10.1080/10409230600914294 URL: http://dx.doi.org/10.1080/10409230600914294 PLEASE SCROLL DOWN FOR ARTICLE Full terms and conditions of use: http://www.informaworld.com/terms-and-conditions-of-access.pdf This article maybe used for research, teaching and private study purposes. Any substantial or systematic reproduction, re-distribution, re-selling, loan or sub-licensing, systematic supply or distribution in any form to anyone is expressly forbidden. The publisher does not give any warranty express or implied or make any representation that the contents will be complete or accurate or up to date. The accuracy of any instructions, formulae and drug doses should be independently verified with primary sources. The publisher shall not be liable for any loss, actions, claims, proceedings, demand or costs or damages whatsoever or howsoever caused arising directly or indirectly in connection with or arising out of the use of this material.
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Downloaded By: [California Digital Library -CDL (CRC journals only) Consortium] At: 16:42 13 Novem Critical Reviews in Biochemistry and Molecular Biology , 41:329–338, 2006 Copyright c Informa Healthcare ISSN: 1040-9238 print / 1549-7798 online DOI: 10.1080/10409230600914294 From Ribosome to Riboswitch: Control of Gene Expression in Bacteria by RNA Structural Rearrangements Frank J. Grundy and Tina M. Henkin Department of Microbiology, The Ohio State University, Columbus, Ohio, USA ABSTRACT Structural elements in the 5 region of a bacterial mRNA can have major effects on expression of downstream coding sequences. Folding of the nascent RNA into the helix of an intrinsic transcriptional terminator results in premature termination of transcription and in failure to synthesize the full- length transcript. Structure in the translation initiation region of an mRNA blocks access of the translation initiation complex to the ribosome binding site, thereby preventing protein synthesis. RNA structures can also affect the stability of an RNA by altering sensitivity to ribonucleases. A wide variety of mechanisms have been uncovered in which changes in mRNA structure in response to a regulatory signal are used to modulate gene expression in bacteria.
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