Week 7 - Week 7 Eukaryotic 16.2 Transcruption in Eukaryotes...

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Week 7 Eukaryotic 16.2 Transcruption in Eukaryotes Proteins called basal transcription factors initiate eukaryotic transcription by matching the enzyme with the appropriate promorter region in the DNA, similar to sigma in bacteria Unlike in bacteria where a single sigma initiates transcription, many basal transcription factors are required to initiation transcription. Eukaryotes have 3 types of RNA RNA Polymerase I: genes that code for most of large RNA molecules, found in ribosomes RNA Polymerase II: genes that code for proteins (produce mRNA) RNA Polymerase III: Genes that code for transfer RNAs and genes that code for small RNA molecules (rRNA) found in ribosomes RNA Pol II and Pol III transcribe molecules found in snrps TATA box is located 30 base pairs upstream of the transcription start site. Exons: are expressed as part of the final mRNA Introns: translated stretches Eukaryotic genes are much longer than their corresponding RNA transcripts because introns are not translated. Primary RNA transcript: contains both the exon and intron regions Introns are removed from the growing RnA strand by splicing and transcription proceeds. Splicing is catalyzed by snRPS, or small nuclear ribonucleuproteins, begins when snRNP binds to the 5’ exon-intron boundary Spliceosome: multipart complex formed by snRPS When splicing occurs the 3’ end of an exon covalenty binds (phopodiester bond) to the 5’
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Week 7 - Week 7 Eukaryotic 16.2 Transcruption in Eukaryotes...

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