lecture72012withnotes

lecture72012withnotes - 1 2 3 Basicity of heterocyclic...

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Unformatted text preview: 1 2 3 Basicity of heterocyclic amines H N N pKb 3.0 pKaH 11 N H H 2.8 H N H N O 4.2 8.4 9.8 11.2 5.6 H N N H H N N H H H O N H H H 4 DNA and RNA delivery 5 Basicity of heterocyclic amines H N N pKb 3.0 pKaH 11 N H H 2.8 H N H N O 4.2 8.4 9.8 11.2 5.6 H N N H H N N H H H O N H H H 6 7 BaylisBaylis-Hillman Reaction 1. Aldol Condensation 8 BaylisBaylis-Hillman Reaction 2. Elimination and formation of -carbonyl product 9 BaylisBaylis-Hillman Reaction 3. Conjugate Addition 10 BaylisBaylis-Hillman Reaction 11 BaylisBaylis-Hillman Reaction 12 BaylisBaylis-Hillman Reaction 13 14 Aziridines and Azetidines – Ring Strain 1. s- Character and Basicity 15 16 Aziridines and Azetidines – Ring Strain 1. s- Character and Basicity 17 Aziridines and Azetidines – Ring Strain 2. Resonance Structures 18 ...
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