Lecture 7 - Lecture 7 Cellular Respiration and Fermentation...

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1/20/2012 1 1 Lecture 7 Cellular Respiration and Fermentation Chapter 9 Part 1 A Little to Finish on Competitive and Non-competitive Inhibitors
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1/20/2012 2 3 Competitive inhibitors- compete for access to active site Noncompetitive inhibitors- bind outside the active site Allosteric site- binding causes conformational change in enzyme active site inhibiting enzyme function Feedback inhibition- product of pathway inhibits early steps to prevent over-accumulation of product Types of Enzyme Inhibitors Fig. 8-19 (a) Normal binding (c) Noncompetitive inhibition (b) Competitive inhibition Noncompetitive inhibitor Active site Competitive inhibitor Substrate Enzyme
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1/20/2012 3 Fig. 8-20 Allosteric enyzme with four subunits Active site (one of four) Regulatory site (one of four) Active form Activator Stabilized active form Oscillation Non- functional active site Inhibitor Inactive form Stabilized inactive form (a) Allosteric activators and inhibitors Substrate Inactive form Stabilized active form (b) Cooperativity: another type of allosteric activation Allosteric Activators and Inhibitors Cooperativity Fig. 8-22 Intermediate C Feedback inhibition Isoleucine used up by cell Enzyme 1 (threonine deaminase) End product (isoleucine) Enzyme 5 Intermediate D Intermediate B Intermediate A Enzyme 4 Enzyme 2 Enzyme 3 Initial substrate (threonine) Threonine in active site Active site available Active site of enzyme 1 no longer binds threonine; pathway is switched off. Isoleucine binds to allosteric site
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1/20/2012 4 RNA as Enzymes: Ribozymes • RNase P Processing tRNA • rRNA (Ribosomes) Peptide bond formation • Splicozomes Splicing out introns in Pre-mRNA If an Inhibitor binds at an Active Site of an Enzyme, it is a _______ inhibitor.
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This note was uploaded on 03/06/2012 for the course ECON 200 Bones taught by Professor Dr.elwonger during the Winter '12 term at Ohio State.

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Lecture 7 - Lecture 7 Cellular Respiration and Fermentation...

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