Slides3 011911(1)

Slides3 011911(1) - Today: 1) Short discussion of ATP and...

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Today: 1) Short discussion of ATP and other carrier molecules 2) Protein folding 3) Exploration of adenylate kinase structure and function
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Ionization state and pH- Acetic acid 90% uncharged 90% charged 1) pH, pKa are on log scale 2) Outside buffering region -Ionic state (charged/uncharged) is more stable -Ionic state (charged/uncharged) predominantes Lehninger 1:1 10:1 1:10
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Figure 2-65 Molecular Biology of the Cell (© Garland Science 2008) “Endergonic” reactions can be driven by: 1) Sequential reactions: exergonic reaction shifts concentration of reactants of previous reaction (siphon) 2) Linked exergonic reactions (Often involving ATP, other NTP’s, other activated carriers) Where linked: NET (Total) Δ G to < 0 ! And:
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Figure 2-57 Molecular Biology of the Cell (© Garland Science 2008) ATP is the most widely used carrier molecule in biological processes What’s so special? α β γ http://www.lesjoforsab.com/standard-springs/compression-springs.asp Pretty stable in cytoplasm Compressed negative charge Large Δ G to < 0 ! “Spring-loaded”
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5 Table 2-5 Molecular Biology of the Cell (© Garland Science 2008) The many carrier molecules found in living cells
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Figure 2-60a Molecular Biology of the Cell (© Garland Science 2008) Reduced forms (NADPH and NADH) are “activated” forms of these electron carriers for functioning in redox reactions Same steps are involved in production of NADH another important electron carrier NADP: nicotinamide adenine dinucleotide phosphate and NAD: nicotinamide adenine dinucleotide are important electron carriers
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7 Figure 2-60b Molecular Biology of the Cell (© Garland Science 2008) NADH and NADPH are not interchangable. They actually function in specific pathways. In the case of NADH, this molecule is used by catabolic pathways as an electron carrier for the ultimate production of ATP. Whereas, NADPH is utilized in anabolic pathways that produce macromolecules important for the biology of the cell. NADP: nicotinamide adenine dinucleotide phosphate and NAD: nicotinamide adenine dinucleotide are important electron carriers
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Figure 2-62 Molecular Biology of the Cell (© Garland Science 2008) Acetyl coA: a carrier molecule that contains a high energy thiol ester bond Fatty acid synthesis
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Figure 2-63 Molecular Biology of the Cell (© Garland Science 2008) Carboxylated biotin is a carrier of a high energy carboxyl group Gluconeogenesis in liver
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Proteins have three dimensional form http://www.c-science.com/txt/images/1999/990406tefax.jpg
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Slides3 011911(1) - Today: 1) Short discussion of ATP and...

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