100411Membrane

100411Membrane - PLASMA MEMBRANE: Lipids and Proteins CELLS...

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PLASMA MEMBRANE: Lipids and Proteins
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CELLS Bacteria Animal cells Animals: Multicellular organisms Ernst Haeckel “Kunstformen der Natur” (1904) Ciliata : Sophisticated cells
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ELECTRON MICROSCOPY OF PLASMA MEMBRANE
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Hydrophilic molecules Hydrophobic molecules PHASE SEPARATION
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Fatty (palmitic) acid AMPHIPATHIC MOLECULES
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MICELLES AND BILAYERS
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LIPOSOMES
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Langmuir’s trough to measure area of the lipid monolayer IS MEMBRANE REALLY A BILAYER? Red blood cells Experiment by Gorter and Grendel , 1925
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MEMBRANE PERMEABILITY
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MEMBRANE FLUIDITY
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PHOSPHATIDYLCHOLINE
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PHASE TRANSITION
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PHOSPHOLIPIDS
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GLYCOLIPIDS
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MEMBRANE BILAYER ASYMMETRY Phosphatidylethonolamine Phosphatidylserine Phosphatidylcholine Sphingomyelin
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CHOLESTEROL
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PHOSPHOLIPID – CHOLESTEROL INTERACTION
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LIPID RAFTS IN ARTIFICIAL LIPOSOMES Phosphatidylcholine + sphingomyelin Phosphatidylcholine + sphingomyelin + cholesterol Atomic force microscopy
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PHOSPHATIDYL-INOSITOLS Phosphorylation Cleavage sites for phospholipases
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CELL MEMBRANES 1. Membranes are designed to enclose and compartmentalize a cell
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This note was uploaded on 03/07/2012 for the course BIOL 212 taught by Professor Kina during the Spring '12 term at UPenn.

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100411Membrane - PLASMA MEMBRANE: Lipids and Proteins CELLS...

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