102011Vesicular transport

102011Vesicular transport - VESICULAR TRANSPORT MEMBRANE...

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VESICULAR TRANSPORT
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MEMBRANE COMPARTMENTS AND TRAFFICKING PATHWAYS
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MEMBRANE COMPARTMENTS AND TRAFFICKING PATHWAYS
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VESICULAR TRANSPORT Budding Scission Transport Fusion
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Figure 13-4 Molecular Biology of the Cell (© Garland Science 2008) COATED VESICLES – TRANSPORT VEHICLES
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DIFFERENT COATED VESICLES FUNCTION AT DIFFERENT LOCATIONS
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CLATHRIN-COATED VESICLES
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CLATHRIN Triskeleon
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CLATHRIN
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ADAPTOR PROTEINS
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CLATHRIN COAT ASSEMBLY PI(4,5) P2 Adaptor protein Cargo Clathrin Other proteins
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Membrane-bending proteins CLATHRIN COAT PI(4,5)P2
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FORMATION OF CLATHRIN-COATED VESICLES Cytosol Extracellular space
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DYNAMIN http://www2.mrc-lmb.cam.ac.uk/NB/McMahon_H/group Dynamin properties: 1. Binds membrane lipids 2. Membrane binding stimulates oligomerization 3. Oligomerizes into rings or helices 4. Dynamin is a GTPase 5. Oligomerization stimulates GTPase activity 6. GTP hydrolysis increases pitch of the helix 7. GTP hydrolysis is cooperative
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Figure 13-12b Molecular Biology of the Cell (© Garland Science 2008) DYNAMIN SPIRALS IN CELLS
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Cytosol Extracellular space PI(4,5)P2 on clathrin-coated vesicles is hydrolyzed allowing uncoating of the vesicle. Clathrin vesicle uncoating is mediated by the chaperone (
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This note was uploaded on 03/07/2012 for the course BIOL 212 taught by Professor Kina during the Spring '12 term at UPenn.

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102011Vesicular transport - VESICULAR TRANSPORT MEMBRANE...

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