102711Signal transduction

102711Signal transduction - SIGNAL TRANSDUCTION SIGNAL...

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SIGNAL TRANSDUCTION SIGNAL TRANSDUCTION
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Neutrophil chasing a bacterium Dictyostelium amoeba responding to  chemoattractant (cAMP) CELLS CAN RESPOND TO EXOGENOUS SIGNALS
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BUDDING YEAST RESPONDING TO MATING FACTOR Shmoo A. Murray Gradient of α -factor
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TYPES OF SIGNALS BETWEEN CELLS
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Figure 15-4 Molecular Biology of the Cell (© Garland Science 2008) TYPES OF SIGNAL TRANSFER Short range signaling Long range signaling
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Figure 15-1 Molecular Biology of the Cell (© Garland Science 2008) GENERIC SIGNALING PATHWAY Signals : Proteins, peptides, amino acids, nucleotides, hormones, dissolved gases Receptors : Transmembrane or cytoplasmic Signaling molecules : Large: Enzymes (kinases, phosphatases, GTPases, etc.) Small: Second messengers (cAMP, cGMP, Ca 2+ , diacylglycerol, etc.) FUNCTION
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Figure 15-18 Molecular Biology of the Cell (© Garland Science 2008) SIGNAL TRANSMISSION: INITIATION AND TERMINATION (C) ALLOSTERIC REGULATION SIGNAL OUT SIGNAL IN
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RECEPTORS Ion channel-linked receptors G-protein-coupled receptors Enzyme-linked receptors Nuclear receptors (Steroid hormones) Cytoplasmic receptors (gases: NO, CO, H 2 S)
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Figure 15-16a Molecular Biology of the Cell (© Garland Science 2008) ION CHANNEL-LINKED RECEPTORS
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ION CHANNEL-LINKED TRANSMEMBRANE RECEPTORS Acetylcholine receptor Neuromuscular junctions Toxins (nicotine, curare, cobra venom)
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Figure 15-16b Molecular Biology of the Cell (© Garland Science 2008) G-PROTEIN-COUPLED RECEPTOR SIGNALING
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GPCR
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This note was uploaded on 03/07/2012 for the course BIOL 212 taught by Professor Kina during the Spring '12 term at UPenn.

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102711Signal transduction - SIGNAL TRANSDUCTION SIGNAL...

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