2010 Exam 3

2010 Exam 3 - NAME: _________ KEY _________________ MIDTERM...

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Unformatted text preview: NAME: _________ KEY _________________ MIDTERM EXAM III - key BIOLOGY 231 10 November 2010 ________________________________________________________________________________ GENERAL INSTRUCTIONS: 1. Answer all questions IN INK, and do not use white-out if you anticipate requesting a re-grade. 2. No calculators. 3. Confine each answer to the BOX or SPACE provided. Only what is clearly written in the box or space will be graded! Use the last 2 pages for rough drafts if you like. 4. SHOW YOUR WORK. SHOW ALL CALCULATIONS. 5. Make sure that your name is PRINTED LEGIBLY on EACH PAGE. 6. This exam consists of 9 questions on 15 pages and it is worth a total of 100 points. Information that might be useful: ! Codon number refers to how many codons away from the AUG you are in an mRNA (with the first AUG = #1). AUG is the start codon; UAA, UGA and UAG are stop codons. ! Use this convention for numbering the residues of a protein: label the first (most N-terminal) residue of the mature protein as 1", then number residues consecutively to the C-terminus. If an N- terminal signal sequence is removed during synthesis, re-number the residues starting with the new N-terminus = 1. ! A hydrophobic signal sequence can be a start-transfer or stop-transfer sequence depending on its position in the polypeptide. Assume that all membrane-spanning portions of proteins have 20 residues. ! Assume that each amino acid residue in a protein has a MW of 100 Da (0.1 kDa). ! An oligomer is a very small polymer, formed by the assembly of a small number of monomeric subunits. ! On this date, 10 November, in 1775, the Continental Congress formed the Marines, as a landing force for the newly created Continental Navy in the Revolutionary War. Also on this date, in 1969, Sesame Street debuted, bringing the world Bert, Ernie, Kermit, Big Bird and Oscar the Grouch. Coincidence?-1- NAME: _________ KEY _________________ MIDTERM EXAM III - key BIOLOGY 231 10 November 2010 ________________________________________________________________________________ (1) 5 pts. A sizes question. NUMBER each of the following molecules so that 1 is the LARGEST and 5 is the SMALLEST . In other words, 5 is the SMALLEST and 1 is the LARGEST : ___ 1 ____ a pancreatic epithelial cell ___ 4 2 ____ PIP , a phospholipid ___ 3 ____ a low density lipoprotein (LDL) particle ___ 2 ____ the endoplasmic reticulum (ER) ___ 5 ____ cholesterol -2- NAME: _________ KEY _________________ MIDTERM EXAM III - key BIOLOGY 231 10 November 2010 ________________________________________________________________________________ (2) You have cloned and sequenced the gene for a membrane protein, the PUGF Receptor, that resides in the plasma membrane, binds an extracellular ligand, and leads to its endocytosis. The mRNA sequence, represented below, contains 4 regions of 20 codons each that encode primarily hydrophobic amino acids. These are shown as white boxes labeled with their boundary codon numbers in the diagram. codon 1 = AUG, codon 351 = UAG. codon 1 = AUG, codon 351 = UAG....
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2010 Exam 3 - NAME: _________ KEY _________________ MIDTERM...

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