2007 Exam 3 - NAME: ____________ KEY _______________...

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Unformatted text preview: NAME: ____________ KEY _______________ MIDTERM EXAM III BIOLOGY 231 7 November 2007 ________________________________________________________________________________-1- GENERAL INSTRUCTIONS: 1. Answer all questions IN INK, and do not use white-out if you anticipate requesting a re-grade. 2. No calculators. 3. Confine each answer to the BOX or SPACE provided. Only what is clearly written in the box or space will be graded! Use the back of the pages for rough drafts if you like. 4. SHOW YOUR WORK. SHOW ALL CALCULATIONS. 5. Make sure that your name is PRINTED LEGIBLY on EACH PAGE. 6. This exam consists of 9 questions on 13 pages and it is worth a total of 98 points. Information that might be useful: ! Use this convention for numbering the residues of a protein: label the first (most N-terminal) residue of the mature protein as 1", then number residues consecutively to the C-terminus. If an N-terminal signal sequence is removed during synthesis, re-number the residues starting with the new N-terminus = 1. ! A hydrophobic signal sequence can be a start-transfer or stop-transfer sequence depending on its position in the polypeptide. ! Codon number refers to how many codons away from the AUG you are in an mRNA (with the first AUG = #1). Residue number refers to how many amino acid residues away from the Nterminus you are in a protein (with the Nterminal aa = #1). ! An oligomer is a very small polymer, formed by the assembly of a small number of monomeric subunits. ! On this day, 7 November, in 1940, the Tacoma Narrows Bridge collapsed. It was then the 3 rd longest suspension bridge in the world but despite its advanced design, it shook itself to pieces when high winds set up a resonating wave in the structure. One dog was killed. The remains of the bridge now sit at the bottom of Puget Sound, where they form the worlds largest man-made reef. NAME: ____________ KEY _______________ MIDTERM EXAM III BIOLOGY 231 7 November 2007 ________________________________________________________________________________-2- (1) 5 pts. A sizes question. NUMBER each of the following molecules so that 1 is the LARGEST and 5 is the SMALLEST: ___ 1 ___ a microtubule ___ 4 ___ phosphotidyl inositol ___ 2 ___ a tubulin dimer ___ 3 ___ -tubulin ___ 5 3 ___ IP , a signaling molecule NAME: ____________ KEY _______________ MIDTERM EXAM III BIOLOGY 231 7 November 2007 ________________________________________________________________________________-3- (2) 14 pts. Consider the 7 mRNAs for membrane proteins shown schematically below. Each grey box indicates a stretch of approximately 30 codons that are mainly hydrophobic; a box under an AUG indicates an N-terminal hydrophobic sequence. Some possible proteins are shown at bottom as they would be arranged in the plasma membrane, with their orientation indicated. For each mRNA, identify the membrane protein that would result from its translation. In the box next to each mRNA, write the number of that protein. If none of the proteins is correct for an mRNA, write none in the box. NAME: ____________...
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This note was uploaded on 03/12/2012 for the course BIO 231 taught by Professor Hollenbeck during the Fall '11 term at Purdue University-West Lafayette.

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2007 Exam 3 - NAME: ____________ KEY _______________...

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