Exam 2 Review
Chapter 19-22
Chapter 19 Carboxylic Acids
-Nomenclature of carboxylic acids
-Characteristic peaks in IR and NMR
-Preparation of carboxylic acids
-Jones reagent on primary alcohol
- KMnO
4
on benzene side chain
- Ozonolysis of alkenes and alkynes
-Acidity of carboxylic acids
- acid on benzene (EWG/EDG o/p or m effect)
- regular acid (inductive effect)
-Amino acids (zwitterions at neutral pH)
Chapter 22 Carboxylic Acid Derivatives
-
Nomenclature
-
Nucleophilic acyl substitution
o
Preparation and utility of acid chloride to prepare most acid derivatives
-
Reactivity of different acid derivatives (will the reaction go?)
-
Transesterification (acid/base conditions)
-
Hydrolysis of acid derivatives (acid and base (saponification) conditions)
-
Reduction of amides (LiAlH
4
) to amine
-
Reduction of esters to alcohol
-
Stop at aldehyde with DIBAL-H
-
Reaction of acid derivatives with organometalic reagents (one or two equivalents can
add)
-
Hydrolysis of a nitrile
Chapter 20 Introduction to Carbonyl Chemistry (Organometallic Reagents)
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- Spring '12
- Gierasch
- Organic chemistry, Carboxylic acid, ketone, Aldehyde, Organometallic Reagents, acid derivatives
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