Case study 1 - Emily Lin Case Study#1 1 The Ciprofloxacin...

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Emily Lin 1/29/2011 Case Study #1 1. The Ciprofloxacin generally targets DNA gyrase and Type II topoisomerase and topoisomerase IV, which are responsible for untangling DNA. This ultimately inhibits the process cell division, stopping the strain from replicating. The reason why the isolate might have an extra copy of the DNA gyrase gene is because then the bacteria diminishes chances of being unsuccessful, and would be able to keep replicating even if one gene was faulty in replication. These gene alleles might be residing in the plasmid, which ensures the perpetuation of the resistance as long as the resistance genes on the plasmid are “copy and pasted” onto MRSA strains. It’s odd that a bacterium would have two alleles of one gene because they are haploid. 2. According to the diagram, “transposition” in Step 2 seems to be a process where the bacteria replicates and makes two cells, one that is exactly the same as the Enterococcus cell donor, and then another with a new plasmid from S. aureus that has the same
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