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Stem Cell Research Project Proposal

Stem Cell Research Project Proposal - If using embryonic...

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Stem Cell Research Project Proposal Lab 3- 2111K-08 Julie W. Bentley-Sikes STEP 1: DEFINE THE PROBLEM After having a pelvic sarcoma resected in 2005, I was left with right foot drop, partial neuropathy of the leg and piriformis muscle in my buttock. These symptoms were due to the severing of two nerves in the pelvic region that have unfortunately not regenerated since. STEP 2: FIND THE RIGHT KIND OF STEM CELL Either embryonic stem cells or umbilical cord stem cells would probably be used. I considered adult stem cells that could be found in the brain, however they have the capacity to differentiate into 1 of 3 different types of nerve cells, (there is no guarantee that the right one would present itself). Embryonic stem cells, used from unused harvested eggs, would be ideal because of their ability to differentiate into practically any type of cell. STEP 3: MATCH THE STEM CELLS WITH THE TRANSPLANT RECIPIENT
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Unformatted text preview: If using embryonic stem cells, rejection would probably be less likely as umbilical cord stem cells come from a living being’s blood that has more mature cells. STEP 4: PUT STEM CELLS IN RIGHT PLACE This would have to be performed surgically, as the injury site is deep within the pelvis and close to the aortic artery. The damaged nerves would need to be located and stem cells placed directly on the damaged area. STEP 5: MAKE THE TRANSPLANTED STEM CELLS PERFORM I can only guess that after putting the stem cells in their correct place that there is not much else to do but pray and wait. It would be interesting to see a clinical study done on a procedure of this type in conjunction with physical therapy. However, there would have to be more than one patient in the experiment so a control is present to see if there was actually any improvement made with the combination vs. surgery alone....
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