Biol0126 tutorial

Biol0126 tutorial - Spleen enlarges to remove excessive...

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Fetal testing can spot many inherited disorders early in pregnancy Amniotic fluid Fetus (14-20 weeks) Placenta Amniotic fluid withdrawn Centrifugation Fetal cells Fluid Uterus Cervix Cell culture Several weeks later Karyotyping Biochemical tests
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Chorionic villus sampling is another procedure that obtains fetal cells for karyotyping Fetus (10-12 weeks) Placenta Chorionic villi Suction Several hours later Fetal cells (from chorionic villi) Karyotyping biochemical tests
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Four α subunits combine to make abnormal hemoglobin Abnormal hemoglobin molecules clump together, altering shape of red blood cells. Abnormal cells carry reduced amount of oxygen. To compensate for reduced oxygen level, medullary cavities of bones enlarge to produce more red blood cells.
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Unformatted text preview: Spleen enlarges to remove excessive number of red blood cells. Too few red blood cells in circulation results in anemia. CBC -(complete blood count) results show Elevated WBC count Elevated reticulocyte (immature RBC) (5-15%) Blood smear normal normal disease disease Pro Val Glu Lys Pro Val Glu Lys a.a. 1 2 3 4 5 6 7 8 . . . Val His Leu Thr Val His Leu Thr Pro Glu Glu Lys Pro Glu Glu Lys a.a. 1 2 3 4 5 6 7 8 . . . Val His Leu Thr Val His Leu Thr normal normal β globin globin normal RBC normal RBC β globin gene globin gene GAG G T G β globin gene globin gene single base change single base change sickled RBC sickled RBC mutated mutated β globin globin...
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Biol0126 tutorial - Spleen enlarges to remove excessive...

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