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03 - How do cells stick to one another to form tissue e.g...

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How do cells stick to one another to form tissue? e.g. How do individual epithelial cells form an epithelium (epithelial tissue)? - Specialized junctions offer structural and functional links between cells Tight junction Adherens junction Gap junction
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Tight junction - Rows of proteins form tight seal by fusing each cell to its neighbors - Prevent substances from leaking across the free surface - Major protein components: occludin, claudin, JAM - Peripheral proteins: ZO-1, ZO-2 cell cell
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Phenotype of claudin-1 knockout mice Impairment of the epidermal barrier in claudin- 1–deficient mice. (A) 12-h-old claudin-1 +/+ , claudin- 1 +/- , and claudin-1 -/- mice. Claudin-1 -/- mice were characterized by wrinkled skin and died within 1 d of birth. (B) Dehydration assay. After Cln1 +/- intercross littermates obtained by Caesarian section at embryonic day 18.5 were resuscitated, their weights were monitored hourly without feeding. Genotyping was performed afterwards. Only Cln1 -/- mice showed rapid and steady weight loss.
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Phenotype of claudin-11 (OSP) knockout mice
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