3A03 Lecture 1 - Derrik - DNA Damage Aging and Cancer...

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DNA Damage, Aging and Cancer Derrik M. Leach PhD Candidate, Dr. A.J. Rainbow Lab Department of Biology
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DNA damage and repair Lecture 1 : Aging, DNA damage; DNA excision repair; Cockayne Syndrome and Xeroderma Pigmentosum Lecture 2 : Strategies for combating aging and cancer.
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Human aging The accumulation of changes in an individual over time Progressive decline in biological function Multidimensional: affects a variety of system to different extents in different individuals Is aging a disease? Is it an abnormal condition affecting the normal function of an individual or and organ system in an individual?
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Human aging The time-dependent functional decline of aging is associated with accumulation of damage in cells and organs. The molecular mechanisms behind these changes are unclear It is well established that DNA alterations are the major factor contributing to cancer The identification of rare inherited disorders known as segmental progeroid syndromes with defective DNA repair supports DNA as a target in the aging process
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Why do we age? Telomere theory Stem cell theory DNA damage/free radical theory
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DNA damage theory of aging Damage accumulates with age as a result of both endogenous and exogenous mutagens Damage genome instability Genomic instability cellular dysfunction via defective chromosome replication, transcription, impaired cellular function,
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