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Lecture 7 - 17:37 The Na K ATPase is very important...

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17:37 The Na +  - K +  ATPase is very important Electrogenic pump – generates negative charge across cell membrane Inside of many cells is about -10 mV, while the outside is 0 mV Pumps 3 positive charges out, 2 positive charges in   deficiency of positive charge  inside cell All living cells have a negative membrane potential Active cells – about 70 to 80 mV Inactive cells – about 10 mV Proton pump Driving force of a gradient of protons chemical potential in concentration Pump out H +  ions, which diffuse back in with sucrose through the Sucrose-H cotransporter Several types of pumps Symport system – both molecules go the same way (Hydrogen and sucrose) Antiport system – The Molecule that is providing the driving force and the molecule  being driven don’t go the same way; one goes in, one goes out The driving molecule doesn’t have to be a proton, and the driving molecule doesn’t have  to be going in and the other coming out. Many variations...usually involve sodium ions 3 other mechanisms – ways for cell to get other stuff in phagocytosis – the cell senses a macromolecule (food) and brings it in to form a  phagocytic vesicle pinocytosis – same thing, except it takes off a chunk of the extracellular fluid, and brings  it in, along with whatever was in there (hormones, etc.)
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