Lecture 13 Feb 23

Lecture 13 Feb 23 - 17:34 Cancer Incorrect regulation of...

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17:34 Cancer Incorrect regulation of division and growth Normal cells: Density-dependent inhibition (surface inhibition: as soon as cells have formed a complete single layer, they stop dividing) If some cells are scraped away, the remaining cells divide to fill the gap and then stop Cancer cells do not exhibit anchorage dependence or density-dependent inhibition Tumor Epithelial cell hyerplasia benign tumor Is not cancerous, but may be seriously pathological Epithelial cell hyperplasia (cell divides more rapidly than normal) dysplasia (cells change form) In situ cancer (cells stay in one place) malignant tumor (cancer – cancer cells invade normal tissue and enter blood and lymph, metastases form at distant site) Lymph generated when blood flows through a capillary and the liquid flows out into tissue Cell spits out microtubules, out of control Some cells lack nuclei, others have huge nuclei with huge DNA, not normal Dysplasias Stages of tumor Orphan Annie cells – no nuclei. Very bad cells!
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Lecture 13 Feb 23 - 17:34 Cancer Incorrect regulation of...

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