Biochemistry 446-midterm II-2011

Biochemistry 446-midterm II-2011 - 1 Biochemistry...

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1 Biochemistry 446-Midterm II April 28 th 2011 Time: 4:30 pm-6:00 pm Lecturer: Cristina C. Clement, Ph.D. 1. Which of the following best describes the citric acid cycle as a central pathway of metabolism? A) It is important for recovery of energy from carbohydrates only. B) It is important for recovery of energy from fatty acids only. C) It is important for recovery of energy from amino acids only. D) It is important for recovery of energy from several metabolic fuels that are broken down to acetyl-CoA. E) Only A) and B) above 2. Which of the following enzymes catalyzes a reaction with the pictured compound as an intermediate? A) α -ketoglutarate dehydrogenase B) succinyl-CoA synthetase C) succinate dehydrogenase D) fumarase E) malate dehydrogenase 3. Which of the following enzymes of the citric acid cycle is inhibited by ATP? A) citrate synthase B) isocitrate dehydrogenase C) α -ketoglutarate dehydrogenase D) succinyl-CoA synthetase E) malate dehydrogenase 4. Which of the following amino acids participates in the transfer of a phosphate group in the reaction catalyzed by succinyl-CoA synthetase? A) aspartate B) glutamate C) histidine D) lysine E) serine 5. Which of the following citric acid cycle intermediates can be converted to aspartate via transamination? A) citrate B) α -ketoglutarate C) succinate D) fumarate E) oxaloacetate COO - CH 2 CH 2 C O O 2- O 3 P
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2 6. Germinating plant seeds can convert acetyl-CoA (obtained from fatty acids stored as oils) into carbohydrates, whereas animals are incapable of converting fatty acids into glucose. This difference is due to the fact that: A) animals have glycogen and don’t need to make glucose from fatty acids. B) plants use the glyoxylate cycle to convert two acetyl CoA to oxaloacetate, a precursor for gluconeogenesis. Animals do not have this cycle. C) plant seeds use photosynthesis to make sugar. D) animals use the citric acid cycle exclusively for energy production, whereas plants do not require much energy and just use glycolysis. E) C and D 7. How many ATP molecules are synthesized from the oxidation of 1 NADH molecule? A) 1 B) 1.5 C) 2 D) 2.5 E) 3 8. Which of the following statements about the mitochondrial inner membrane is FALSE? A)The inner membrane is permeable to CO 2 , H 2 O, and small ions. B) The inner membrane contains about 75% protein. C) The inner membrane contains many respiratory proteins. D) The inner membrane is highly invaginated. 9. Several prosthetic groups act as redox centers in Complex I, including A) FMN, ubiquinone, iron-sulfur clusters, heme. B) FMN, ubiquinone, iron-sulfur clusters. C) heme, ubiquinone, iron-sulfur clusters. D) all of the above E) none of the above 10. The functional core of Complex III includes: A)cytochrome c 1 , iron-sulfur protein (Rieske). B)cytochrome
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Biochemistry 446-midterm II-2011 - 1 Biochemistry...

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