AT Lecture 7

AT Lecture 7 - BISC 330L Biochemistry Spring Semester 2012 USC Lecture 7 Wed 25 January 2012 1 More Chapter 2 material Review Tertiary Structure

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BISC 330L: Biochemistry Spring Semester 2012 USC Lecture 7: Wed, 25 January 2012 1. More Chapter 2 material… Review Tertiary Structure Quaternary Structure Predicting α/β character
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BISC 330L Midterm #1 (175 pts) Tues, 31 Jan 4:00 – 4:50pm Sit every other seat. Write in pen. Bring USC ID card. If you are enrolled in: Please take the exam in: 11am lecture [13023] THH 201 12pm lecture [13024] THH 101
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Tertiary Structure Shows conformation of the whole polypeptide Stabilized by noncovalent bonds Can be studied by X-ray crystallography Proteins can be: fibrous (long and extended) globular (blobs) Ras
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Examples of Protein Tertiary Structures F.A. Binding Protein (mainly β) Myoglobin (mainly α) Green Fluorescent Protein (mainly β) [Ser-Tyr-Gly] αβ Barrel Triosphosphate Isomerase
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http://www.tsienlab.ucsd.edu/Images.htm Agar Plate of Fluorescent Bacteria Colonies
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Motifs ( supersecondary structure ) Motifs are small combinations of secondary structure Consecutive sequences of primary structure; not distant
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Helix-Loop-Helix Motif: Alpha helical segments separated by an intervening loop HLH domain preceded by a stretch of basic aa whose + charged side chains contact DNA (bHLH) Proteins (MyoD) with bHLH motifs occur as dimers or heterodimers
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Zinc Finger Motif : Zinc ion of each finger is coordinated to two cysteines and two histidines Cysteines are part of two stranded beta sheet on one side
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This note was uploaded on 03/15/2012 for the course BISC 330L taught by Professor Petruska,tower during the Spring '07 term at USC.

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AT Lecture 7 - BISC 330L Biochemistry Spring Semester 2012 USC Lecture 7 Wed 25 January 2012 1 More Chapter 2 material Review Tertiary Structure

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