AT Lecture 11

AT Lecture 11 - BISC 330L Biochemistry Spring Semester 2012...

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BISC 330L: Biochemistry Spring Semester 2012 USC Lecture 11: Friday, 03 February 2012 1. Chapter 4: Flow of Genetic Information Review RNA/DNA structure Watson-Crick proposal Current events in biochemistry
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Chapter 4: DNA, RNA, and the Flow of Genetic Information DNA RNA PROTEIN PROTEIN
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The Watson- Crick Proposal DNA composed of two chains Two chains spiral around each other Sugar-phosphate backbone on the outsid Bases situated inside double helix; perpendicular to long axis Major and minor grooves One turn of helix / 10 nucleotides Two chains are complementary and antiparallel H-bonds between bases Pyrimidines always pair with purines
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Importance of Watson- Crick Model 5’ 3’ 3’ 5’ Determining the structure had TWO important outcomes: 1. Gave rise to obvious and testable hypotheses about how genetic information could be stored and duplicated. 2. Gave rise to the starting point for the development of techniques to study DNA
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Erwin Chargaff showed that base composition (%) varies from organism to organism. Organism A T C G E. coli 40 40 10 10 Human 30 30 20 20 Mycobacterium 15 15 35 35 Chargaff’s Rules: %A = %T and %G = %C BUT : (%A + %T) did NOT equal the (%G + %C)
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The General Structure of the Nucleotide The sugar in all nucleotides is a pentose sugar DNA and RNA each have four types of bases Without the phosphate group, it would be called a “nucleoside” Base P O Sugar P P
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Ribose vs. Deoxyribose RNA DNA
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This note was uploaded on 03/15/2012 for the course BISC 330L taught by Professor Petruska,tower during the Spring '07 term at USC.

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AT Lecture 11 - BISC 330L Biochemistry Spring Semester 2012...

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