AT Lecture 15

AT Lecture 15 - BISC 330L: Biochemistry Spring Semester...

Info iconThis preview shows pages 1–7. Sign up to view the full content.

View Full Document Right Arrow Icon
BISC 330L: Biochemistry Spring Semester 2012 USC Lecture 15: Monday 13 February 2012 1. Chapter 8 – Enzymes: Basic Concepts and Kinetics K M and V max k cat /K M Three types of inhibitors
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
K M and V max K M is [S] at V max /2 K M is a measure of the strength of ES High K M = Weak Low K M = Strong • V max is turnover number V max = k 2 [E] T
Background image of page 2
What is k cat /K M ? V o = k cat /K M [S][E] (14)+(20) • [S]<<K M so V o = k cat /K M [S][E] T k cat /K M is a measure of catalytic efficiency k cat is rate of catalysis K M is strength of E-S interaction Catalytically perfect enzymes
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Catalytically perfect enzymes: k cat /K M between 10 8 - 10 9 s -1 M -1
Background image of page 4
Types of inhibitors Irreversible Reversible Competitive Uncompetitive Noncompetitive http://alexandria.healthlibrary.ca/documents/notes/bom/unit_1/L-20%20Enzymes%201%20and%202.xml
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
The ES complex
Background image of page 6
Image of page 7
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 03/15/2012 for the course BISC 330L taught by Professor Petruska,tower during the Spring '07 term at USC.

Page1 / 27

AT Lecture 15 - BISC 330L: Biochemistry Spring Semester...

This preview shows document pages 1 - 7. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online