AT Lecture 16

AT Lecture 16 - BISC 330L Biochemistry Spring Semester 2012...

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BISC 330L: Biochemistry Spring Semester 2012 USC Lecture 17: Friday 17 February 2012 1. Chapter 10 – Regulatory Strategies of Enzymes Allosteric regulation Isozymes Covalent modifications Activation by proteolytic cleavage
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BISC 330L Midterm #2 (175 pts) Tues, 21 Feb 4:00 – 4:50pm Sit every other seat. Write in pen. Bring USC ID card.
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Material on Midterm 2 Lecture 9: 30 Jan Lecture 10: 1 Feb Lecture 11: 3 Feb Lecture 12: 6 Feb Lecture 13: 8 Feb Lecture 14: 10 Feb Lecture 15: 13 Feb Lecture 17: 17 Feb
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Chapter 10: Regulation of enzymatic activity Allosteric control Multiple forms of enzymes Reversible covalent modification Proteolytic activation Controlling amount of enzyme present
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Aspartate Transcarbamoylase (ATCase) Allosteric regulation Biosynthesis of CTP Feedback inhibition
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Structure of ATCase Catalytic subunits (c 3 ) • Regulatory subunits (r 2 ) • Complex = 2c 3 + 3r 2 ==> c 6 r 6
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ATCase exists in 2 forms: T state and R state 2 quaternary forms PALA: bisubstrate analog T (tense): compact, inactive R (relaxed): expanded
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AT Lecture 16 - BISC 330L Biochemistry Spring Semester 2012...

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